rPbPga1 from Paracoccidioides brasiliensis Activates Mast Cells and Macrophages via NFkB
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منابع مشابه
rPbPga1 from Paracoccidioides brasiliensis Activates Mast Cells and Macrophages via NFkB
BACKGROUND The fungus Paracoccidioides brasiliensis is the leading etiological agent of paracoccidioidomycosis (PCM), a systemic granulomatous disease that typically affects the lungs. Cell wall components of P. brasiliensis interact with host cells and influence the pathogenesis of PCM. In yeast, many glycosylphosphatidylinositol (GPI)-anchored proteins are important in the initial contact wit...
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Transmission electron microscopy was used to study ultrastructures in Paracoccidioides brasiliensis yeast cells after ingestion by nonactivated or cytokine-activated murine peritoneal macrophages. Yeast cells ingested by nonactivated macrophages had typical bi- and trilayered cell walls, plasma membranes, mitochondria, nuclei, vacuoles, etc., which remained intact for 24 h of coculture. In cont...
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Paracoccidioides brasiliensis, the etiologic agent of paracoccidioidomycosis, is a dimorphic fungus, which is found as mycelia at 22-26 degrees C and as yeasts at 37 degrees C. A remarkable feature common to several pathogenic fungi is their ability to differentiate from mycelium to yeast morphologies, or vice-versa. Although P. brasiliensis is a recognized pathogen for humans, little is known ...
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In the present study we evaluated T cell proliferation and Th lymphokine patterns in response to gp43 from Paracoccidioides brasiliensis presented by isolated dendritic cells from susceptible and resistant mice. T cell proliferation assays showed that dendritic cells from susceptible mice were less efficient than those from resistant mice. The pattern of T cell lymphokines stimulated by dendrit...
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The yeastlike form of Paracoccidioides brasiliensis strain IVIC Pb9 reduced the amount of a-1,3-glucan in its cell wall from 45 to 3% when subcultured in vitro for several years. This strain regained its a-1,3-glucan up to 25% of the total cell wall when grown in vivo. A mutant strain of P. brasiliensis Pb9, named IVIC Pbl4O, reported to have 1,3-mannan instead of a-glucan in the cell wall, cou...
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ژورنال
عنوان ژورنال: PLOS Neglected Tropical Diseases
سال: 2015
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0004032